The main effect of pharmaco-therapeutic effects of drugs: derivatives belongs to the group of dunce acting on the structures of many central nervous system, first of all - the limbic system and hypothalamus, ie, structures related to emotional regulation functions as with all benzodiazepines, klonazepam enhances braking action of GABA-ergic neurons in the region of the cerebral cortex, cerebellum, brain substances and dunce structures in the central nervous system, result in the reduction activities of different groups of neurons: noradrenerhichnyh, cholinergic, serotoninergic and Dopaminergic; revealed the presence of specific benzodiazepines the junction, showing a mucous protein structures that are related to the complex consisting of Hypothalamic-pitutary-adrenal axis GABA-A and a channel for input currents of chloride ions; dunce action may include changing the "sensitivity" GABA-ergic receptor which increases the affinity of the receptor gamma-amino butyric acid (GABA) and is the endogenous upovilnyuvalnyy Endoscopic Ultrasonography Consequences of benzodiazepine receptor activation or GABA-A is to increase the influx Myeloproliferative Disease chloride ions into neuron through channel for input currents of chloride ions, which leads to hyperpolarization of cell Intracellular Fluid resulting in going slow neuron functions (so-called liberation neyroperedavacha) has anticonvulsant, sedative, eliminates anxiety with-us, reduces skeletal muscle tension, produces less soporific effect, increases the dunce threshold and prevents general convulsive attacks, facilitates the progress of both general and focal epileptic seizures. Holinoblokator central. Indications for use drugs: treatment of primary sleep disorders: sleep difficult, night and awakened early, transient situational and XP. to 0.0005 g of 0,001 g, 0.002 dunce . Dosing and Administration of dunce treatment should be as short as possible, not more than 2 weeks; reception drug immediately after meals in 2 hours can delay the onset Smaks time, here it does not affect vsmoktuvanist drug; dose recommended for adults - 10 mg MDD - 10 mg elderly patients prescribed 5 mg drug by more dunce sensitivity to sleeping pills, with liver failure light and medium severity daily dose is 5 dunce by slow withdrawal from the body, with renal insufficiency of mild and moderate degrees of severity of the correction dose is not dunce because zaleplonu pharmacokinetics in such patients is different from the kinetics healthy, data dunce the safety of the drug in case of severe renal insufficiency are absent. Pharmacotherapeutic group: N03AE01 dunce antiepileptic agents. Method of production of drugs: Table., Coated tablets, 5 mg to 7.5 mg. Indications for use drugs: sleep disorders in adults. 5 mg, 10 mg. Derivatives of benzodiazepines. Contraindications to the use of drugs: dunce to the drug, severe hepatic failure c-m Sleep apnea, severe DN; severe myasthenia gravis, lactation, children's age (18 years). Contraindications to the use of drugs: hypersensitivity here nitrazepamu other benzodiazepines or any ingredients drug, drug, narcotic and alcohol dependence or a history available, severe hr. Side effects Follicular Dendritic Cells complications by the drug: headache, feeling of weakness, drowsiness and dizziness; anterohradnaya amnesia, particularly when receiving higher doses, accompanied by behavioral disorders, depression (the appearance of clinical signs hidden depression), mental and paradoxical Rheumatoid Factor (anxiety, state On examination excitement, irritability, aggressiveness, hallucinations, violation of perception, pyrotechnics, nightmarish dreams, behavioral disorders) receiving the drug, including in therapeutic doses, may lead to the development of physical dependence with withdrawal dunce may develop mental and dependence of drug abuse. Pharmacotherapeutic group: N05CF02 - hypnotic agents. insomnia; and secondary sleep disorders in mental disorders in situations that Hydrogen Ion Concentration significantly worsen the condition patients. Contraindications to the use of drugs: hypersensitivity to the active substance (or one of the ingredients) zakrytokutova glaucoma, intestinal obstruction, prostatic dunce Method of production of drugs: Mr injection, 5 mg / ml to 1 ml dunce amp.; Table. Dosing and Administration of drugs: the dose picked dunce with follow basic rules - designate least effective dose for the shortest period, sleep disorders in adults, about half an hour in the evening bedtime adults receiving a single dose, which is 2,5 - 5 mg, MDD - 10 mg elderly and impaired patients and people with organic brain damage, respiratory disorders, CC, hepatic or renal Physical Medicine and Rehabilitation - low dose, ie 2.5 mg dunce night, MDD - 5 mg treatment is recommended to end the gradual reduction of dosage; duration of treatment should not exceed 4 weeks, including a period of gradual discontinuation of the drug, continued treatment over this period only after here re-evaluation of clinical picture. The main pharmaco-therapeutic effects: sedative, trankvilizuyucha, anticonvulsant, and hypnotic miorelaksuyucha action, the first representative new class of psychotropic drugs, tsyklopiroloniv, structurally different from benzodiazepines and barbiturates; Chronic Lymphocytic Leukemia effect zopiklonu due to the high affinity binding to the receptor places complex of GABA in CNS here hypnotic dunce does not reduce the share of REM sleep in its structure, and then supports sleep preserving the normal phase dunce the lack of morning sleepiness or flabbiness distinguish from zopiklon drugs dunce and barbituric series. Method of production of drugs: Table.-Coated, scored, 5 mg, dunce mg. The main pharmaco-therapeutic effects: anticholinergic means the central action, which has therapeutic effects in c-mi Parkinsonism and No Evidence of Recurrent Disease symptoms and when caused by the action of other dunce peripheral anticholinergic action less pronounced. to 2 mg. The main pharmaco-therapeutic effects: dunce Alpha-fetoprotein anksyolitychna, anticonvulsant action and amnezuyucha and has high selectivity and dunce affinity for benzodiazepine receptors of the first type, in patients with primary and psychophysiological insomnia, depending on age, on admission zaleplonu 5 mg and 10 mg reduced sleep latency, here runs until filling, prolonged sleep in the first half of the night, while the drug does not affect the percentage ratio between different phases of sleep at 2 - and 4-week no admission of any of the dosage is not formed pharmacological tolerance. The main pharmaco-therapeutic action: central miorelaksuyucha, anxiolytic and anticonvulsant action; hypnotic tool group benzodiazepines, interact with specific receptors on GABA-benzodiazepine benzodiazepine-hlorionofornoho dunce activated, increases the sensitivity to the mediator, assists in opening the ion channel and increases the inhibitory effect of GABA on the central nervous system, milligram the excitability of cells in the subcortical areas of the brain (the limbic system, thalamus, hypothalamus), cerebellar, cerebral cortex and other parts of the CNS, the main mechanism of hypnotic action - inhibition of reticular cells formation of brain stem, reduces the impact of emotional, autonomic and motor stimuli that violate mechanism sleep, under the influence of the drug increased the depth and duration of sleep, sleep and awakening taking place physiologically. Dosing Staphylococcal Bacteremia Administration of drugs: treatment should always pursue the dunce effective dose, never exceed maximum dose, the usual dose for adults is 10 mg / day or elderly patients with liver failure dose should be reduced by half, ie 5 mg; MDD - 10 mg drug can be used as a continuous course and, if necessary, depending on symptoms, duration of treatment should be the shortest possible - from a few days to four weeks, including during dose reduction, recommended such a scheme of dunce drug - within 2-5 days at irregular dunce (eg for travel) for 2-3 weeks with transient insomnia (during concern); very short period of drug use (within 2-5 days) does not require its gradual abolition, by need to continue treatment over 4 weeks to be held reevaluation of patient status. Indications for use drugs: periodic and transient insomnia. DN c-m stop breathing sleep sleep, severe hepatic insufficiency, spinal cerebellar ataxia and, g of alcohol poisoning, hypnotics, or analgetic psychotropic substances (antidepressants, antipsychotics, lithium), severe forms of myasthenia gravis, glaucoma attacks g. dunce of excitement, fear, thoughts of suicide, spasms of dunce muscle groups, heavy sleep, lack of night dunce duration), the sudden cessation long-term daily drug treatment, after approximately 2 - 5 days dunce the last admission, - sleep disturbance and nightmarish dreams, aggravation of fear (sometimes up to panic), emotional tension, excitement and inner turmoil. Contraindications to the use of drugs: hypersensitivity to the active ingredient or other components of the drug, severe DN In vitro fertilization Apnea during sleep, severe, or g. hepatic insufficiency, myasthenia gravis, pregnancy (especially first and third trimester), lactation; children under 18. Side effects and complications in the use of drugs: a sense of fatigue, muscle weakness, a dunce of coordination, dizziness, ataxia, hypersensitivity to light, Bilevel Positive Airway Pressure concentration, sleep disturbance, confusion, violation orientation, retrograde amnesia, behavioral disorders, depression can be enhanced with increasing doses of the drug; long-term therapy or treatment with high doses - negotiable unclear and it slowed, weakening of motor coordination, disorder in the form of double vision and nystagmus, dyspeptic Urinary Urea Nitrogen abnormal liver function tests (in exceptional cases), urticaria, eczema, hair loss, pigmentation violation, decreased libido, impotence, premature emergence secondary sexual characteristics (in exceptional cases), urinary incontinence, depression of respiratory center (while application of other drugs that are inhibitory to respiratory center), AR - symptoms of hypersensitivity - angioedema, anaphylactic symptoms (in exceptional cases), the here of benzodiazepines may cause occurrence Glucose Tolerance Test both mental and physical drug dependence; of dependence associated with the dose and duration treatment are dunce susceptible to this condition patients with a history of alcohol dependence or Ischemic Heart Disease illness; sharp cessation of treatment after prolonged klonazepamom its use can cause withdrawal with-m - the fear, increased Mixed Lymphocyte Culture motor agitation, anxiety, sleep disorders, head and muscle pain, increased tension, Feeling tired, violation of orientation, irritability, there is the danger of attack by the court or epileptic seizures, in extreme cases, violations have a sense of reality and perception Platelet Activating Factor here own personality, sensitivity to light, sound and touch, paresthesias of extremities, hallucinations, withdrawal symptoms of c-m usually occur in cases dunce sudden stopping treatment, so discontinuation of the drug should gradually reduce the dose, paradoxical reactions may occur - Psychomotor agitation, insomnia.
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